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Watch Carefully (1)pentobarbital will decrease the extent or outcome of fentanyl by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Carefully. Coadministration of fentanyl with CYP3A4 inducers may lead to your lessen in fentanyl plasma concentrations, not enough efficacy or, perhaps, advancement of the withdrawal syndr